Team‎ > ‎

Dr. Veronique Maes



Office: C101A

+32 (11) 26 8296
veronique.maes@uhasselt.be
 

Brief Curriculum Vitae

Since 11/2013 Postdoctoral Researcher, prof. dr. T. Junkers, Polymer Reaction Design Group, Hasselt University, Hasselt (Belgium).
  • FISCH ATOM project

12/2012 -
10/2014

R&D Chemist, "Chemical Engineering towards Organic Electronics", prof. dr. W. Maes, Design and Synthesis of Organic Semiconductors, Hasselt University, Hasselt (Belgium).
10/2006
10/2013

Postdoctoral Researcher (FWO-scholarship), prof. dr. D. Tourwé, Organic & Medicinal Chemistry, Vrije Universiteit Brussel, Brussels (Belgium).
10/2002 -
09/2006
PhD in Chemistry (FWO-scholarship), "Radiolabeled Peptides for Diagnosis & Therapy of Cancer", Organic & Medicinal Chemistry, prof. dr. D. Tourwé, Vrije Universiteit Brussel, Brussels (Belgium).
01/2002 -
09/2002

Assisting Academic Co-worker, prof. dr. D. Tourwé, Organic & Medicinal Chemistry, Vrije Universiteit Brussel, Brussels (Belgium).
10/1997 -
07/2001

Master of Science: Chemistry (Organic Chemistry), Vrije Universiteit Brussel, Brussels (Belgium).
  • Master Dissertation: "The [3,3]-sigmatrope restructuring of Z-1-amino-2-phenylcyclopropanecarboxylic acid derivatives and the study of using cycling 1H-NMR", Organic and Medicinal Chemistry, prof. dr. D. Tourwé, Vrije Universiteit Brussel, Brussels (Belgium).
09/1991 - 
07/1997
 Secondary School (ASO, Latin-Math option physics and chemistry).

Publications

(21)
Synthetic Routes Towards asymmetrically substituted (funcionalized) 4H-cyclopenta[2,1-b:3,4-b']dithiophenes 
W. Vanormelingen, P. Verstappen, V. Maes, D. Bevk, L. Lutsen, D. Vanderzande, W. Maes, Synlett 2013, 24 (18), 2389-2392.

(20)
Chapter 3: Aspects of Peptidomimetics 
V. Maes, D. Tourwé, Peptide and Protein Design for Biopharmaceutical Applications, 2009, J. Wiley.

(19) PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues 
S. Daepp, C. Müller, E. Garcia-Grayoa, P. Bläuenstein, V. Maes, L. Brans, D. Tourwé, R. Schibli, Eur. J. Nucl. Med. Mol. Imaging 2012, 2 (24), 2-12.

(18) PEGylation of 99mTc-labeled bombesin analogues improves their pharmacokinetic properties
S. Daepp, E. Garcia-Grayoa, V. Maes, L. Brans, D. Tourwé, C. Müller, R. Schibli, Nucl. Med. Biol. 2011, 38, 997-1009.

(17) Synthesis and Evaluation of Bombesin Analogues Conjugated to Two Different Triazolyl-Derived Chelators for 99mTc Labeling
L. Brans, E. Garcia-Grayoa, C. Schweinsberg, V. Maes, H. Struthers, R. Schibli, D. Tourwé, Chem. Med. Chem. 2010, 5, 1717-1725.

(16) Bis(thiosemicarbazones) as bifunctional chelators for the room temperature labelling of peptides and proteins
R. Heuting, M. Christlieb, J. Dilworth, E. Garcia-Grayoa, V. Gouverneur, M. Jones, V. Maes, R. Schibli, D. Tourwé, Dalton Trans 2010, 39, 3620-3632. 

(15) Novel neurotensin analogues for radioisotope targeting to neurotensin receptor-positive tumours
F. Al Shoukr, C. Rosant, V. Maes, J. Abdelhak, O. Raguin, S. Burg, L. Sarda, J. Barbet, D. Tourwé, D. Pelaprat, A. Gruaz-Guyon, Bioconj. Chem. 2009, 20, 1602-1610.

(14) A stable neurotensin-based radiopharmaceutical for targeted imaging and therapy of neurotensin receptor-positive tumours
E. Garcia-Garayoa, P. Bläuenstein, A. Blanc, V. Maes, D. Tourwé, P. A. Schubiger, Eur. J. Nucl. Med. Mol. Imaging 2009, 36, 37-47.

(13) Glycation methods for bombesin analogs containing the (N His)Ac chelator for 99mTc(CO)3 radiolabeling
L. Brans, V. Maes, C. Schweinsberg, E. Garcia-Garayoa, P. Bläuenstein, D. A. Tourwé, Chem. Biol. Drug Design 2008, 72, 496-506.

(12) Influence of the molecular charge on the biodistribution of bombesin analogs labeled with the [99mTc(CO)3]-core
E. G. Garayoa, C. Schweinsberg, V. Maes, L. Brans, P. Bläuenstein, D. A. Tourwé, R.Schibli, P. A. Schubiger, Bioconjugate Chem. 2008, 19, 2409-2416.

(11) Novel Glycated [99mTc(CO)3]-labeled Bombesin Analogues for Improved Targeting of Gastrin-Releasing Peptide Receptor-Positive Tumors
C. Schweinsberg, V. Maes, L. Brans, P. Bläuenstein, D. A. Tourwé, P. A. Schubiger, R.Schibli, E. G. Garayoa, Bioconjugate Chem. 2008, 19, 2432-2439.

(10) New 99mTc-bombesin analogues with improved biodistribution for targeting GRP receptor-positive tumors
E. Garcia-Garayoa, C. Schweinsberg, V. Maes, A. Blanc, P. Bläuenstein, D. A. Tourwé, P. A. Schubiger, Q. J. Nucl. Med. Mol. Imaging 2007, 51, 42-50.

(9) Chemical and Biological Characterization of new Re(CO)3/99mTc(CO)3 bombesin analogs
E. Garcia-Garayoa, D. Rüegg, P. Bläuenstein, M. Zwimpfer, V. Maes, I. U- Khan, A. Blanc, A. G. Beck-Sickinger, D. A. Tourwé, P. A. Schubiger, Nucl. Med. Biol. 2007, 34, 17-28.

(8) "Click to Chelate": Synthesis and Installation of Metal Chelators into Biomolecules in a Single Step
T. L. Mindt, H. Struthers, L. Brans, T. Anguelov, C. Schweinsberg, V. Maes, D. Tourwé, R. Schibli, J. Am Chem. Soc. 2006, 128, 15096-15097.

(7) Toward stable N4-modified neurotensin for NTS1-receptor-targeted tumor imaging with 99mTc
B. A. Nock, A. Nikolopoulou, J.-C. Reubi, V. Maes, P. Conrath, D. Tourwé, T. Maina, J. Med. Chem. 2006, 49, 4767-4776.

(6) Spatial conformation and topography of the tyrosine aromatic ring substrate recognition by protein tyrosine kinases
P. Ruzza, L. Cesaro, D. Tourwé, A. Calderan, B. Biondi, V. Maes, I. Menegazzo, A. Osler, C. Rubini, A. Guiotto, L. A. Pinna, G. Borin, A. Donella-Deana, J. Med. Chem. 2006, 49, 1916-1924.

(5) Fluorescein Labeled Stable Neurotensin Derivatives
V. Maes, C. Hultsch, S. Kohl, R. Bergmann, T. Hanke, D. Tourwé, J. Pept. Sci. 2006, 12, 505-508.

(4) Maillard Glycation of Peptides Containing the (N His)Ac chelator for 99mTc(CO)3 Labeling
V. Maes, D. Tourwé, Int. J. Pept. Res. Therapeutics 2006, 3, 197-202.

(3) Novel 99mTc-Labeled Neurotensin Analogs With Optimized Biodistribution Properties
V. Maes, E. Garcia-Garayoa, P. Bläuenstein, D. Tourwé, J. Med. Chem. 2006, 5, 1833-1836.

(2) Double-stabilized neurotensin analogues as potential radiopharmaceuticals for NTR-positive tumors
E. Garcia-Garayoa, V. Maes, P. Bläuenstein, A. Blanc, A. Hohn, D. Tourwé, P. A. Schubiger, Nucl. Med. & Biol. 2006, 33, 495-503.

(1) Synthesis of Side-Chain Adapted -Turn Mimics for Modifying the C-Terminus of Substance P
V. Pawar, W. M. De Borggraeve, V. Maes, D. A. Tourwé, F. Compernolle, G. J. Hoornaert, Tetrahedron Letters 2006, 46, 1707-1710.



Abstract and Conference Presentations


Talks: 

(2)
Meeting ETH/PSI, 2006, Zürich (Switzerland)
"Radiolabeled peptides for cancer diagnosis and therapy. Glycation of bombesin analogs"

(1)8th Sigma-Aldrich Organic Synthesis Meeting, 2004, Spa (Belgium)
"Synthesis of metabolically stable 99m Tc-labeled neurotensin(8-13) analogs for tumor diagnosis"


Posters:

(21)"Improved tumour imaging and therapy with radiolabeled PEGylated bombesin analogues"
31st European Peptide Symposium 2010, September 5-9, 2010, Copenhagen (Denmark)
(20)"Bis(thiosemicarbazones as bifunctional chelators for the room-temperature 64-copper labeling of peptides and proteins"
SNM Annual Meeting 2010, June 5-9, 2010, Salt Lake City (US)

(19)"Optimization of the polarity of radiolabeled bombesin(7-14) provides excellent tracers for tumor detection using SPECT"
4th International congress NP2D Natural Peptides to Drugs 2010, April 11-14, 2010, Zermatt (Switzerland)

(18)"Improving pharmacokinetic properties of radiolabeled bombesin analogues by incorporation of polar groups"
30th European Peptide Symposium 2008, September 1-5, 2008, Helsinki (Finland)

(17)"Influence of the charge on the in vivo behaviour of radiolabeled bombesin analogues"
30th European Peptide Symposium 2008, September 1-5, 2008, Helsinki (Finland)

(16)"Radiolabeled peptides: click chemistry for chelator construction and glycation"
11th Sigma-Aldrich Organic Chemistry Meeting 2007, December, 2007, Spa (Belgium)

(15)"Influence of the spacer on the biodistribution of radiolabeled bombesin analogues"
Annual Congress of the European Association of Nuclear Medicine EANM 07, October 13-17, 2007, Copenhagen (Denmark)

(14)"Double targeting of prostate cancer xenografts with radiolabeled neurotensin and bombesin analogues"
Annual Congress of the European Association of Nuclear Medicine EANM 07, October 13-17, 2007, Copenhagen (Denmark)

(13)"Click-carbohydrated [99mTc(CO)3](N-His)Ac-bombesin(7-14) analogs"
20th American Peptide Society Symposium 2007, June, 2007, Montréal (Canada)

(12)"Preclinical evaluation of new stabilized bombesin analogues with new polar spacers"
8th Annual Congress of Swiss Society for Nuclear Medicine 2007, June, 2007, Basel (Switzerland)

(11)"Functionalizing and Modification of Bombesin Analogues using "click"-chemistry"
17th International Symposium on Radiopharmaceutical Sciences 2007, April 30 - May 4, 2007, Aachen (Germany)

(10)"Influence of polar spacers on the biodistribution of 99mTc-labeled bombesin analogues"
17th International Symposium on Radiopharmaceutical Sciences 2007, April 30 - May 4, 2007, Aachen (Germany)

(9)"Influence of the spacer on the biodistribution of radiolabeled bombesin analogues"
Annual Congress of EANM 06, September 30 - October 4, 2006, Athens (Greece)

(8)"Click to chelate: simultaneous synthesis and introduction of polydentate metal chelators into biomolecules for diagnostic and therapeutic applications"
232nd ACS Meeting 2007, September, 2007, San Francisco (US)

(7) "Technetium-99m-tricarbonyl: Preclinical evaluation of new stabilized bombesin analogues with different polar spacers"
Annual Congress of the Swiss Society of Nuclear Medicine (SSNM) 2006, June 1-3, 2006, Lausanne (Switzerland)

(6)"Bombesin Analogues for targeting of gastrin releasing peptide receptors in human tumor tissues"
10th Swiss Receptor Workshop 'From Research to Therapeutics' 2006, March 12 - 15, 2006, Basel (Switzerland)

(5)"Improvement of the biodistribution properties of metabolically stable 99mTc-labeled neurotensin(8-13) analogues"
6th Australian Peptide Conference 2005, Hamilton Island (Australia)

(4)"Neuropeptide analogues labeled with the radionuclides Tc-99m and Re-188 for tumour diagnosis and therapy"
28th European Peptide Symposium 2004, Prague (Czech Republic)

(3)"Synthesis of metabolically stable 99mTc-labeled neurotensin(8-13) analogs for tumor diagnosis"
28th European Peptide Symposium 2004, Prague (Czech Republic)

(2)"Synthesis of metabolically stable 99mTc-labeled neurotensin(8-13) analogs for tumor diagnosis"
7th Sigma-Aldrich Organic Synthesis Meeting 2003, (Belgium)

(1)"Synthesis of functionalized cis-amino piperidinone carboxylate beta-turn mimetic analogues and their incorporation into substance (P(6-11)"
7th Sigma-Aldrich Organic Synthesis Meeting 2003, (Belgium)